Repair of meniscus using mesenchymal cells with magnetic targeting method

为提高半月板损伤的愈合效果，应用间充质细胞-磁珠复合体评价关节腔内注射间充质细胞治疗半月板损伤的疗效。首先，将SD大鼠(SD大鼠)的MSC注射到半月板损伤的SD大鼠的膝关节内。其次，将人骨髓间充质干细胞按相同的方法注射到裸鼠的膝关节内。然而，磁靶向法在两种模型中均未观察到细胞外基质显著增加。

Efficacy of intraarticular injection of mesenchymal cells (MSC) for meniscus injury was evaluated using MSC-magnetic beads complex in order to improve healing effect on injured meniscus. Firstly, MSC of Sprague-Dawley rats (SD rat) were injected into the knee of SD rats with injured meniscus. Secondary, human MSC were also injected into the knee of nude rats using the same protocol. However, no remarkable increase of extracellular matrices were observed by using the magnetic targeting method in the both models.