Clinical trial of Spinal Cord Regeneration Treatment by Transplanting Olfactory Ensheathing Cells (OECs) in Dogs

本研究旨在研究鼻黏膜源性OECs移植治疗脊髓损伤截瘫犬临床病例脊髓功能再生的临床试验。但是我不能将这种疗法应用到任何病例中，因为狗的主人不同意这个临床试验，尽管有很多狗可以成为候选人。因此，我建立了一种不开颅，经鼻腔内镜活检获取嗅粘膜的新方法。此外，我还研究了犬硬膜外导管电极电生理检查，以选择细胞移植治疗病例并确定治疗效果。

The purpose of this study was a clinical trial of nasal mucosa derived OECs transplantation therapy to regenerate the function of the spinal cord in the clinical cases of dogs with paraplegia due to spinal cord injury. However I could not apply the therapy to any case because the owner of dogs did not agree with this clinical trial, although there were many dogs which could become candidate. Therefore I established new method to harvest the olfactory mucosa without craniotomy by endoscopic biopsy via nasal cavity. In addition I studied electrophysiological examination using extradural catheter electrode in dogs to select cases for cell transplantation therapy and to decide the efficacy of the therapy.