Role of obestatin in anxiety disorders

胃分泌胃促生长素，大脑也会分泌它。据报道，胃饥饿素与抑郁、焦虑和饮食行为有关。GPR39是胃饥饿素的受体。我们研究了肥胖、抑郁、焦虑和饮食行为之间的关系。将GPR39-1b反义寡核苷酸等速注入大鼠侧脑室，观察其对焦虑和食物摄入的影响。GPR39-1b反义寡核苷酸在升高+迷宫试验和黑白试验中产生抗焦虑样作用。GPR39-1b反义寡核苷酸减少食物摄取量。这些结果表明，抑制GPR39-1b可导致焦虑相关行为的减少和食欲的紊乱。

Stomach secretes ghrelin, and brain also doses it. Ghrelin have reported to be associated with depression, anxiety and eating behavior. GPR39 is a receptor for ghrelin. We examined the relationship between obestatin, depression, anxiety and eating behavior. We GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test, and in the black and white test. GPR39-1b antisense oligonucleotides decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite.