The role of cancer-host interaction in the invasion of lung adenocarcinoma

应用免疫组织化学方法检测63例手术切除的原发性肺腺癌组织中NECL-5的表达。癌细胞Necl-5的过表达与肿瘤的淋巴结转移、TNM分期及细支气管肺泡癌的比例显著相关。此外，Necl-5过表达阳性患者的无瘤生存率显著低于Necl-5过表达阴性患者。提示NCEL-5在介导肿瘤细胞侵袭中起重要作用，肿瘤细胞中NCEL-5的过表达对评估原发性肺腺癌患者的预后有临床意义。

A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis, TNM staging and the bronchioloalveolar carcinoma ratio of tumors. Furthermore, the disease-free survival rate in patients with positive Necl-5 overexpression was significantly lower than that in patients with negative Necl-5 overexpression. These results indicate that Necl-5 plays a role in mediating tumor cell invasion and that the overexpression of Necl-5 in cancer cells has clinical significance for prognostic evaluation of patients with primary pulmonary adenocarcinoma.