The mechanisms responsible for the recovery of the beta-adrenoceptor function in the alveolar epithelium of lung injury

在肺损伤的肺中研究了肺泡上皮细胞中β-肾上腺素受体恢复的机制。首先，我们研究了晚期糖基化终产物受体（Receptor for Advanced Glycation End-products）在基因敲除小鼠中的作用，发现晚期糖基化终产物受体（Receptor for Advanced Glycation End-products）在小鼠呼吸机诱导的肺损伤中不起作用。第二，肾功能衰竭大鼠肺泡液体清除功能下降。而内源性儿茶酚胺在肾功能衰竭大鼠中可增加肺泡液体清除率，在肺水肿的防治中起重要作用。第三，由于谷氨酸降低了大鼠的基础肺泡液体清除率，β-2肾上腺素能激动剂增加了给予谷氨酸的大鼠的肺泡液体清除率，因此建议不应在肺水肿和肺损伤患者中给予谷氨酸。氨基酸平衡对维持肺泡液体清除功能可能有重要作用。第四，海水中高浓度镁不改变基础肺泡液体清除率和β-肾上腺素能受体激动剂在肺泡液体清除中的作用。β-肾上腺素能激动剂可能是治疗海水溺水者的有效药物。最后，水通道蛋白在肺癌的侵袭和转移中起重要作用.本研究表明，研究肺损伤后β受体恢复的机制具有重要意义。

The mechanisms responsible for the recovery of beta-adrenoceptor in the alveolar epithelium were studied in the lungs with lung injury. First, we studied the role of RAGE (Receptor for advanced glycation end-products) in the knockout mice without RAGE and found that RAGE did not play a role in ventilator-induced lung injury in mice. Second, the function of alveolar fluid clearance decreased in rat with renal failure. But, the endogenous catecholamine in the rat with renal failure increased alveolar fluid clearance and played an important role in the prevention of pulmonary edema. Third, since glutamic acid decreased basal alveolar fluid clearance in rats and beta-2 adrenergic agonist increased alveolar fluid clearance in rats with an administration of glutamic acid, it is suggested that glutamic acid should not be administered in patients with pulmonary edema and lung injury. The balance of amino acid may be important to maintain the function of alveolar fluid clearance. Fourth, the high concentration of magnesium as that in seawater did not change basal alveolar fluid clearance and the function of beta-adrenergic agonist in alveolar fluid clearance. The beta-adrenergic agonist may be a potent agent in the treatment of drowned people of seawater. Finally, aquaporin played an important role invasion and metastasis of lung cancer. This study indicates that it is important to study the mechanism responsible for the recovery of beta-adrenoceptor in lung injury.