Effect of ultra short-acting β1-adrenergic receptor blocker on cardiac muscle as an immunomodulation therapy under excessive stress.

对全身炎症反应综合征(SIRS)所致的阵发性心房颤动(房颤)患者给予短效选择性β受体阻滞剂兰地洛尔治疗，观察心率和血压的变化，测定心脏指数等血流动力学参数，并检测血清炎症细胞因子水平。接下来，我们比较了兰地洛尔、地高辛、西比林和维拉帕米对SIRS引起的阵发性心房颤动和快速室性反应患者的疗效。兰地洛尔肯定会降低心率，而不会导致血压大幅下降。兰地洛尔降低心脏指数，增加每搏输出量指数。兰地洛尔可降低血清IL-6水平。兰地洛尔对心率的减慢作用强于其他药物。兰地洛尔的降压效果与西比林和维拉帕米相当。兰地洛尔的药理复律成功率高于地高辛组和维拉帕米组，与西比林相当。

Patients of paroxysmal atrial fibrillation with a rapid ventricular response caused by SIRS were injected with landiolol, a short-acting selective β1-adrenergic receptor blocker and the changes in heart rate and blood pressure were recorded, hemodynamic parameters including cardiac index were measured, and the serum levels of inflammatory cytokines were measured. Next, we compared the effects of landiolol, digoxin, cibenzoline, and verapamil for patients with paroxysmal atrial fibrillation and a rapid ventricular response caused by SIRS. Landiolol certainly decreased the heart rate without inducing a massive decline in blood pressure. Landiolol decreased cardiac index, but increased the stroke volume index. Landiolol decreased the serum levels of interleukin-6. Landiolol decreased the heart rate more than the other drugs. The blood pressure lowering effect of landiolol was comparable to those of cibenzoline and verapamil. The success rate of pharmacological cardioversion using landiolol was higher than that using digoxin or verapamil, and was nearly equal to that using cibenzoline.