Studies of aphthous stomatitis on the response to glucocorticoids or immunocompetence of γδT cells.

口疮的发病机制尚未完全阐明，诊断完全基于目前的病史和临床表现。因此，目前还没有作为诊断基础的客观指南。目前还没有建立根本性的治疗方法，目前只提供姑息治疗。在目前的研究中，我们调查了压力和免疫机制的作用，这是已知的口腔炎的原因。唾液压力标记物的测量显示，这些标记物可能会因个体对口腔炎的敏感性而不同。这些结果表明，免疫细胞中的时钟基因可能是糖皮质激素(GC)诱导表达的，γδT细胞具有免疫活性。此外，还发现昼夜节律直接受到压力信号的影响。以上结果提示，口疮的发生可能与应激引起的GC变化和昼夜节律异常有关。

The mechanism of onset of aphtha has not been well-elucidated, and diagnosis of aphtha is based entirely on current medical history and clinical findings. As a result, no objective guidelines that serve as the basis of diagnosis are currently available. No fundamental treatments have been established, and only palliative care is given at present. In the present study, we investigated the roles of stress and immune mechanisms, which are known to be causes of aphthous stomatitis. Measurement of salivary stress markers revealed the possibility that these markers vary depending on the sensitivity of the individual to stomatitis. The results indicated the possibility that clock genes in immunocytes are inducibly expressed in response to glucocorticoids (GC), and that γδT cells have immunocompetence. In addition, the circadian rhythm was found to be directly influenced by stress signals. The above findings suggest that onset of aphtha may be related to variations in GC caused by stress and abnormalities in circadian rhythm.