Proteomics of Porphyromonas gingivalis within a model oral microbial community

牙龈卟啉单胞菌可以组装成一个异型社区与中间殖民者F.nucleatum和早期殖民者S.gordonii，和社区生活方式提供的生理支持牙龈卟啉单胞菌。结果表明，在相同条件下，牙龈卟啉单胞菌与三种模型菌共培养1156个蛋白质，其中下调蛋白403个，上调蛋白89个。与硫胺素、钴胺素和嘧啶合成有关的蛋白质显著减少。这些结果表明，社区的生活方式提供了牙龈卟啉单胞菌的生理支持。

P.gingivalis can assemble into a heterotypic community with a middle colonizer F.nucleatum and an early colonizer S.gordonii, and that a community lifestyle provides physiologic support for P.gingivalis. 1156 P.gingivalis proteins, including 403 down-regulated and 89 up-regulated proteins, were detected qualitatively during comparison of the three species model community with P.gingivalis incubated alone under the same conditions. Significant decreases were seen in proteins involved in thiamine, cobalamin, and pyrimidine synthesis. These results indicate that a community lifestyle provides physiologic support for P.gingivalis.