Structure of the essential Commander protein trafficking complex

该项目旨在提供对Commander的结构和功能的基本理解，Commander是一种大型蛋白质复合物，控制内化受体的输出和回收。Commander在整个进化过程中高度保守，对于维持细胞功能和生存所需的数百种跨膜受体的稳态，调节脂质代谢和细胞粘附等多种过程至关重要。尽管对Commander功能的了解有所进展，但对Commander如何组装并与其他必需蛋白质相互作用知之甚少。该项目将使用多学科细胞和结构生物学方法在原子水平上揭示指挥官的结构。

This project aims to provide a fundamental understanding of the structure and function of Commander, a large protein complex that controls export and recycling of internalised receptors. Commander is highly conserved throughout evolution and is essential for maintaining the homeostasis of hundreds of transmembrane receptors required for cell function and survival, regulating processes as diverse as lipid metabolism and cell adhesion. Despite advances in the understanding of Commander function, little is known about how Commander is assembled and interacts with other essential proteins. This project will use multidisciplinary cellular and structural biology approaches to reveal the architecture of Commander at an atomic level.