Insect host/vector genetic responses to rhabdovirus infection

弹状病毒会导致人类、动物和植物的重要疾病。这些病毒通过昆虫媒介传播，它们在其中持续和繁殖，这是一种密切和特定的联系。将使用飞虱-玉米弹状病毒模型在分子水平上研究昆虫-弹状病毒的相互作用。将使用基因组学和生物信息学工具识别和表征由弹状病毒感染特异性诱导的昆虫基因以及病毒基因本身。我们将扩展相同的方法，将这些飞虱基因与我们研究所正在研究的其他昆虫-弹状病毒系统进行比较分析。识别在昆虫中表达的病毒基因，识别对病毒感染作出反应的昆虫基因，并解释这些基因在昆虫中的作用，可能为通过控制病毒传播来控制严重的动植物疾病提供新的机会。

Rhabdoviruses cause important diseases in humans, animals and plants. These viruses are transmitted by insect vectors in which they persist and propagate, an intimate and specific association. Insect-rhabdovirus interactions will be studied at the molecular level using a planthopper-maize rhabdovirus model. Insect genes specifically induced by rhabdovirus infection as well as the viral genes themselves will be identified and characterized using genomics and bioinformatics tools. We will extend the same approaches to a comparative analysis of these planthopper genes with other insect-rhabdovirus systems under investigation in our institutes. Identification of viral genes expressed in insects, the insect genes that respond to virus infection, and interpretation of the roles of these genes in insects, may indicate new opportunities to control serious plant and animal diseases through control of virus transmission.