Development of a novel minimally invasive treatment of cancer using magnetic nanoparticles to recognize molecular target and energy

将人乳腺癌细胞株(BT474、SKBr3)接种于裸鼠小腿筋膜下建立肿瘤模型。与抗体结合的脂质体可以调节并保持稳定，直径小于100 nm，内含抗癌药物，密封在脂双层(FeFe204)磁铁矿之间。在给予抗体、化学和热疗的组中，这种系统治疗不仅显示出肿瘤的缩小，而且对淋巴转移也有治疗作用。如上所述，计划的研究目的是可以实现的。

Tumor model was achieved by implantation of human breast cancer cell line(BT474, SKBr3) under the fascia of the lower leg of nude mouse. Liposomes bound to antibody could be adjusted and kept stable below 100nm in diameter contained anticancer drugs inside, sealed between lipid bilayer(FeFe204) magnetite. In the group given antibody, chemical and thermal, such systemic therapy showed not only a reduction in tumor size but also a therapeutic effect against the lymph node metastases. As described above, the planned research purposes could be achieved.