PHYSIOLOGICAL FUNCTIONS OF WATER-SOLUBLE FLAVONOID DERIVATIVES IN OSTEOPOROTIC RODENTS

由于天然黄酮类化合物是典型的疏水化合物，因此这些化合物并不经常被用作多功能食品添加剂。酶法修饰的大豆异黄酮橙皮苷和环糊精包合橙皮苷是一种柑橘生物黄酮类化合物，其水溶性高于天然相应的黄酮类化合物。这些水溶性黄酮衍生物具有很高的生物利用度，尤其是CD-橙皮素改善了断奶和老年2型糖尿病啮齿动物的继发性骨质疏松症。

Since native flavonoids are typical hydrophobic compounds, the compounds have not been frequently used as multipurpose food additives. Enzymatic modified-soy bean isoflavone and hesperidin, and cyclodextrin-clathrated(CD) hesperetin, a citrus bioflavonoid, have higher water-solubility than native corresponding flavonoids. Those water-soluble flavonoid derivates showed high bioavailability, and especially, CD-hesperetin improved secondary osteoporosis in both weanling and old type 2 diabetic rodents.