Neue synthetische Methoden für Eisen-, Kobalt-, Mangan- oder Nickel-katalysierte Kreuzkupplungen

金属催化的交叉偶联反应是形成新的碳-碳键的重要反应。通常使用钯络合物和在一定程度上使用镍络合物。这两种金属催化剂都有一些缺点（中等的转化率、金属价格、毒性、化学选择性和立体选择性）。在这个提议中，我们建议调查新的交叉偶联反应，使用非常规的金属，如铁，锰，钴，钌和铑配合物与官能化的芳基镁和烯基镁化合物。多官能杂环化合物是重要的合成目标。作为第二个主题，我们建议进行carbocuprations的各种炔与多官能有机铜物种在分子内，如果可能的话，在分子间的方式。我们还计划在闭环反应中使用我们实验室共同开发的新型多官能镁试剂，以合成高度官能化的杂环。最后，探索性的工作是利用钯配合物对未活化的芳环位置进行C-H活化。

Metal-catalyzed cross-coupling reactions are very important reactions for forming new carbon-carbon bonds. Palladium and to some extent nickel complexes have been generally used. Both of these metal-catalyses have some drawbacks (moderate turnovers, metal price, toxicity, chemoselectivity and stereoselectivity). In this proposal, we propose to investigate new cross-coupling reactions using unconventional metals like iron, manganese, cobalt, ruthenium and rhodium complexes with functionalized arylmagnesium and alkenylmagnesium compounds. Polyfunctional heterocycles are important synthetic targets. We propose as a second topic to perform carbocuprations of various alkynes with polyfunctional organocopper species in an intramolecular and if possible in an intermolecular fashion. We plan also to use the new polyfunctional magnesium reagents jointly developed in our laboratories in ring closure reactions for the synthesis of highly functionalised heterocycles. Finally, exploratory work will be perform C-H activations of unactivated aromatic ring positions by palladium complexes.