The efficacy of cannabinoids to the various keratoderma.

我们发现，大麻素和香草素激动剂诱导表皮角质形成细胞表达SERCA2分别是通过CB2和TRPV3/4受体的直接作用。外敷以Darier‘s和银屑病模型小鼠为代表的遗传性炎症性角化病，我们发现尤其是大麻素类药物带来了显著的病理效应，包括一层肉芽肿的恢复，而凡尼类药物没有带来如此强烈的影响。我相信大麻类激动剂可以成为未来治疗过度角化性皮肤病的很好的候选药物。

We showed that the strong induction of SERCA2 expression in the epidermal keratinocytes after the treatments with cannabinoid and vanilloid agonists are direct effects through CB2 and TRPV3/4 receptor, respectively. Also the external application on the Darier's and psoriatic model mouse as a representative of hereditary and inflammatory keratosis, we found that especially the cannabinoids brought about the significant pathological effects which include the a recovery of a stratum granulosum, while vanniloid did not bring such strong impact. I believe that the cannabinoids agonist can be a good candidate of the future therapeutic drug against the hyperkeratotic skin diseases.