Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats

最近有证据表明，合成抗氧化剂没食子酸正丙酯（PG）在培养细胞的常氧条件下激活缺氧诱导因子1 （HIF-1）。本研究旨在验证PG可减轻大鼠前脑缺血模型神经元损伤的假设。结果表明，腹膜给药半胱氨酸正丙酯可能对中度（8min）而非重度（10min）前脑缺血大鼠模型具有神经保护作用。

Recent evidence indicated that n-propyl gallate (PG), a synthetic antioxidant, activates hypoxia-inducible factor 1 (HIF-1) under normoxic conditions in cultured cells. The present study was conducted to test the hypothesis that the administration of PG may attenuate neuronal injury in a rat model of forebrain ischemia. The results indicated that intraperitoneal administration of n-propyl galate may have neuroprotective effects in a model of moderate(8min), but not severe(10min), forebrain ischemia in rats.