Animal model development and research for understanding the pathogenesis of hypertrophic scar and development of therapeutic agent

增生性瘢痕是创伤和手术后的一个毁灭性问题。玛丽的研究已经取得了广泛的成果，但其病理生理机制仍不清楚，治疗药物也没有突破性进展。其中一个原因是缺乏良好的增生性瘢痕动物模型。雌性红毛猪（Female Red Droc Pig，FRDP）是一种新型的动物模型，但由于体型较大，体重超过200Kg，操作困难，实验空间大，本研究采用的小型猪爪形模型，其瘢痕与人类增生性瘢痕完全相容，具有良好的实验性，可作为研究的动物模型。我们发现组织糜酶活性与增生性瘢痕的厚度密切相关。我们推测糜酶参与了增生性瘢痕的病理生理过程，抗糜酶药物是治疗增生性瘢痕的潜在有效药物。

Hypertrophic scaring is a devastating problem after trauma and surgery. Mary researches have been extensively achieved, but the pathophysiology is still unknown and no therapeutic agent breakthrough. One of this reason is the lack of good animal model for hypertrophic scaring. Female Red Droc Pig(FRDP) is a novel animal model but the pig become very big and body weight becomes over 200Kg and handling of the pig is very difficult and need large space for experiments.The clawn miniature swine which we used, is much easier to use in the study and confirmed that it's scar is fully compatible to human hypertrophic scar.Using this model, we found that the tissue chymase activity was deeply related to the thickness of the hypertrophic scar. We speculate that chymase participate in the pathophysiology of hypertrophic scar and anti-chymase agents is potentially effective therapeutic agent for hypertrophic scarring.