The possibility of the gut flora as a new health index-validation from the association between exercise, lifestyle and the gut flora

利用分子生物学技术建立了一种简便的肠道植物群测定方法。本研究利用该方法检测了普通人群肠道植物群的表达特征，验证了肠道植物群表达模式的观察是否可以作为新的健康指标和生活方式相关疾病的筛查指标。本研究中的所有调查内容都与岩城健康促进项目的健康检查结果进行了比较，结果显示，瘦人群的OTU332（乳酸菌）的表达率显著高于肥胖人群和标准人群。提示肥胖与肠道植物群的表达模式密切相关，是生活方式相关疾病之一，是生活方式相关疾病的主要危险因素。这一结果表明，乳酸菌可能成为肥胖的保护因子。此外，我们现在正在考虑和详细分析除肥胖外的生活方式相关疾病与肠道植物群表达模式之间的关联。

The simple measuring method of the gut flora using the molecular biological technique was developed recently. We examined the characteristic of the expression patterns of the gut flora using this method in general populations.We verified whether observing the expression patterns of the gut flora would be effective as new health indicator and a screening index of a lifestyle-related disease. We examined all survey contents in this study with the result of the health-check up in the Iwaki Health Promotion Project.The expression ratio of OTU332 (lactic acid bacterium) in the lean person group was significantly higher than those in the obesity group and the standard group in this result. This result suggested that obesity was significantly related to the expression patterns of gut flora, and it was one of the lifestyle-related diseases and the main risk factor of the lifestyle-related disease. This result suggested that a lactic acid bacterium might become the obese protective factors.In addition, we are considered and analyzing in details now about the associations between lifestyle related diseases expect for obesity and the expression pattern of gut flora.