Whether insulin can act as a neurotrophic factor in olfactory sensation

我们用免疫组化方法建立了嗅粘膜胰岛素受体的表达。钙调神经磷酸酶抑制剂特异性地降低了培养的牛肾上腺嗜铬细胞中IRS-2蛋白水平50%，而不改变IRS-2 mRNA水平，以及胰岛素受体、胰岛素样生长因子-I受体、IRS-1、PI 3 K/PDK-1/Akt/GSK-3β和ERK 1/ERK 2蛋白水平。此外，我们检查了长期接触砷的人的嗅觉。小感觉障碍占51%，嗅觉障碍占22%。

We established the expression of insulin receptor in the olfactory mucosa by immunostaining method.The calcineurin inhibition decreased specifically IRS-2 protein level by 50% in cultured bovine adrenal chromaffin cells, without changing IRS-2 mRNA level, and insulin receptor, insulin-like growth factor-I receptor, IRS-1, PI3K/PDK-1/Akt/GSK-3β and ERK1/ERK2 protein levels.Additionally, we examined olfactory sensation of persons who had the long term exposure of arsenicum. The impaired sense of small was 51%, and the olfactory anesthesia was 22%.