Analysis of optimal dose of anticancer drug in superselective intra-arterial infusion using computational fluid dynamics based on biomedical engineering

为了阐明口腔癌动脉内化疗中抗癌药物在肿瘤供血动脉或转移淋巴结中的分布情况，我们利用计算流体力学对颈外动脉及其分支的血流进行了模拟。为了进行准确的模拟，我们应用了带外周网络的OD模型，并利用颞浅动脉的血流对模拟进行了评估。该模拟的误差在5%左右，为颈外动脉及其分支的患者特异性血流模拟奠定了基础。

To clarify distribution of anticancer drug to tumor feeding artery or metastatic lymph node in intra-arterial infusion for oral cancer, we developed blood flow simulation of the external carotid artery and its branch using computational fluid dynamics. For accurate simulation, we applied 0D model with peripheral network and assessment of the simulation was performed using blood flow of the superficial temporal artery. The error of this simulation was about 5%, and the base of patient-specific blood flow simulation of the external carotid artery and its branch was established.