Asymmetric endocytosis across the growth cone that controls axon guidance

神经元回路是由被拉长并到达目标的轴突形成的。每个轴突的尖端，被称为生长锥，探索细胞外的引导线索，并可以转向适当的方向。在这个项目中，我们发现排斥信号通过胞质Ca^<2+>信号引起生长锥的不对称内吞作用，并且这种不对称内吞作用对于排斥引导既是必要的也是充分的。我们还发现，胞吞作用和胞吐作用之间的局部不平衡驱动生长锥转向。

Neuronal circuits are formed by axons that have elongated and reached their targets. The tip of each axon, called the growth cone, explores extracellular guidance cues and can turn in the appropriate direction. In this project, we found that repulsive cues cause asymmetric endocytosis across the growth cone via cytosolic Ca^<2+> signals and that this asymmetric endocytosis is both necessary and sufficient for repulsive guidance. We also showed that a localized imbalance between endocytosis and exocytosis drives growth cone turning.