Design of proline analogues based on hybrid methods and their application

折叠成明确的二级结构的肽的从头设计在诸如有机化学、生物科学和材料科学的各种领域中至关重要。控制多肽构象的方法已经被研究，并且作为稳定多肽二级结构的模板，α，α-二取代α-氨基酸已经被广泛使用。本论文中，我们合成了脯氨酸类似物和稳定的短螺旋肽，并将其应用于（E）-查耳酮的不对称环氧化反应。

The de novo design of peptides that fold into well-defined secondary structures is crucially important in a wide variety of fields such as organic chemistry, and biological and material sciences. Approaches to controlling the conformations of peptides have been studied, and as templates for stabilizing the secondary structures of peptides, α, α-disubstituted α-amino acids have been widely used. In this study, we demonstrated the synthesis of proline analogues and stabilized short helical peptides, and their application to the enantioselective epoxidation of (E)-chalcone.