Development of novel catalytic reactions of alkyne derivatives for the construction of heterocycles

我们开发了基于以下每个反应的连续成键方法来有效地合成杂环化合物：1)通过Au催化的Claisen重排反应合成高取代的吡咯和呋喃；2)通过钯催化的环化-烯丙化序列或无金属氧化环化反应同时合成恶唑和呋喃类化合物或含氧官能团；以及3)通过杂烯丙基歧化反应合成二氢喹啉和亚氨基喹诺酮类化合物。

We developed efficient synthetic methods of heterocyclic compounds by means of consecutive bond formation approaches based on each of the following reactions : 1) syntheses of highly substituted pyrroles and furans via Au-catalyzed Claisen rearrangement reactions, 2) syntheses of oxazoles and furans concomitantly with incorporation of allyl gropes or oxygen functional gropes via Pd-catalyzed cyclization-allylation sequences or metal-free oxidative cyclization reactions, and 3) syntheses of dihydroquinolines and iminoquinolinones via hetero en-yne metatheses.