Design, synthesis, and application of carborane-containing functional molecules based upon intermolecular interactions

碳硼烷的高疏水性和酸性C-H氢的合理组合提供了各种人工受体。在合成的阴离子受体中，三碳硼烷衍生物在脂质体氯离子转运实验中显示出氯离子通道的特性。一些三碳硼烷类似物对氯离子表现出比母体化合物更强的缔合常数，对各种阴离子表现出不同的选择性。为了了解碳硼烷笼的疏水相互作用，并将含碳硼烷的化合物应用于药物，环糊精和各种碳硼烷衍生物之间的络合物的物理化学性质被揭示。

A rational combination of high hydrophobicity and acidic C-H hydrogens of carboranes afforded various artificial receptors. Among synthesized anion receptors, tricarborane derivative showed the property of chloride ion channel in chloride transport assay using liposome. Some tricarborane analogues showed a more potent association constant for chloride anion than the parent compound and a different selectivity for various anions. To understand hydrophobic interactions of carborane cages and apply carborane-containing compounds to medicinal drugs, the physicochemical properties about the complexation between cyclodextrins and various carborane derivatives are revealed.