The timing to establish the circadian rhythms in development

通过观察细胞周期指标Fucci Tg小鼠SCN内神经元从胎儿到成年逐渐发育。SCN中的背内侧作为起搏点比背外侧发展得更快，以重置昼夜节律的相位。这一结果与Per1：luc Tg小鼠自出生后1周开始的昼夜节律自主振荡相一致。比较孕鼠与交配雄鼠或其他雄鼠饲养后仔鼠SCN分化情况。对母鼠的不规则刺激会影响小白鼠SCN的发育。提示在正常环境中饲养母亲对建立幼鼠昼夜节律有重要意义。

The neurons in the SCN were developed gradually from fetal to adult by observing cell cycle indicator Fucci Tg mouse. The Dorso Medial in the SCN as pacemaker was developed faster than the Ventro lateral to reset the phase of circadian rhythms. This result was consistent that the circadian rhythms oscillated autonomously since 1week after birth from Per1 : luc Tg mice. The SCN differentiation in pups were compared after pregnant mother mice was kept with mating male or other male. Development in pubs SCN tends to be affected by irregular stimulation to mother mice. It suggests that it is important to keep mother in normal environment for establishing pubs circadian rhythms.