Mechanism identification of fat graft regeneration and angiogenesis with adipose-derived stem cells.

在本研究中，我们证明了血管生成潜能在组织再生和干细胞植入中起着重要的作用，特别是脂肪干细胞具有表达许多具有血管生成作用的生长因子的特性，如血管内皮生长因子、成纤维细胞生长因子-2和肝细胞生长因子，在低氧条件下，这些生长因子的表达通过低氧诱导因子-α的表达而增强。由于局部血流和血管生成对组织植入和再生起着至关重要的作用，干细胞在利用脂肪干细胞进行组织再生中起着关键作用。

In the present study, we have demonstrated that angiogenic potential plays an important role in tissue regeneration and stem cell engraftment and that adipose-derived stem cells, in particular, has a property toprodece many growth factors with angiogenic action, such as vascular endothelial growth factor, Fibroblast growth factor-2, and hepatocyte growth factor, which is enhanced via Hypoxia inducible factor-alpha expression under hypoxia conditions. As local blood flow and angiogenesis plays a crucial role for tissue engraftment and regeneration, it has been clarified that stem cell plays a key role in tissue regeneration using adipose-derived stem cell.