How organisms coordinate energy supply and demand

代谢应激敏感蛋白激酶又称AMP激活蛋白激酶，控制着所有真核生物的代谢，以满足能量需求和营养供应的需要。它负责加速新陈代谢(葡萄糖运输、糖酵解和脂肪酸氧化)以响应能量需求，并在热量限制的情况下调节基因转录以适应能量供应。本项目旨在提供对AMP激活的蛋白激酶(酶的异构体、基因、生理作用和调节)的全面了解。这些知识将在生物制药开发、家畜、植物和体育/赛马业中产生重大好处。

The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive understanding of the AMP activated protein kinase (enzyme isoforms, genes, physiological roles and regulation). This knowledge will have major benefits in biopharmaceutical development, the livestock, plant and sport/racing industries.