Systems therapeutics for metabolism: AMPK isoform specific drugs

代谢系统疗法：AMPK 亚型特异性药物

• 批准号: DP1092675
• 负责人: Prof Bruce Kemp
• 金额: $ 24.72万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092675
• 关键词: Systems; therapeutics; metabolism; AMPK; isoform

Living cells have to maintain a steady balance between energy production and consumption in order to function properly. A key regulator of energy balance is an enzyme known as 5' AMP-activated protein kinase (AMPK), which regulates the burning and storage of fuels such as fat and sugars, in response to changes in energy demand. This project will provide a major advancement in our understanding of the regulation of AMPK at the molecular level, and lay the foundations for the development of more effective drugs to treat energy balance disorders such as obesity and Type 2 diabetes. Furthermore, this proposal will contribute to enriching Australia's international profile and competitiveness in this important area of research.

活细胞必须在能量产生和消耗之间保持稳定的平衡，以便正常工作。 能量平衡的关键调节因子是一种称为5'AMP-活化蛋白激酶（AMPK）的酶，其响应于能量需求的变化来调节燃料（如脂肪和糖）的燃烧和储存。 该项目将为我们在分子水平上对AMPK调控的理解提供重大进展，并为开发更有效的药物治疗肥胖和2型糖尿病等能量平衡障碍奠定基础。 此外，这项建议将有助于丰富澳大利亚在这一重要研究领域的国际形象和竞争力。