Establishment of the systems that regulate the activity of tumor-related factors for tumor suppression

我们发现了新的肿瘤相关因子的分子机制。我们还建立了细胞渗透性肿瘤抑制因子的表达系统，用于肿瘤抑制的蛋白治疗。(1)发现与肿瘤生长相关的转录因子DP-1蛋白稳定性有重要意义的“Stabilon”基序。(2)发现SOCS7和新的TRIP6亚型对TRIP6介导的LPA信号转导的抑制作用。(3)大肠杆菌的建立。细胞渗透性RARa、SOCS-3、p53和SOCS-2的表达系统。

We discovered the newly molecular mechanisms of tumor-related factors. We also established that the expression system of cell-permeable tumor suppressors for the protein therapy of tumor suppression.(1) Identification of "Stabilon" motif that is significant for protein stability of transcription factor DP-1 concerned with tumor growth.(2) Discovery of the suppression of TRIP6-mediated LPA signal transduction by SOCS7 and new isoforms of TRIP6.(3) Establishment of E. coli. expression system of cell-permeable RARa, SOCS-3, p53 and SOCS-2.