Ion-specific biological effect of heavy ion near the Bragg peak

重离子作为癌症治疗的辐射源已在实际应用中，这是目前最有效的治疗技术之一。在本工作中，我们研究了重离子在布拉格峰附近的生物效应，该区域显示了能量沉积的急剧增加。我们定量分析了细胞失活和DSB诱导率，并证明了这些生物效应之间的系统相关性的物理性质的离子。我们还发现，大多数诱导的DSB是不可修复的，这是由于DNA损伤的复杂性。此外，我们还发现DSB末端的结构差异取决于离子种类的证据。

Heavy-ions are in practical use as a radiation source for cancer-therapy, which is now one of the most effective techniques for treatments. In this work, we investigated the biological effectiveness of heavy ion near the Bragg peak, which region shows the drastic increase of energy deposition. We quantitatively analyzed the cell inactivation and DSB induction rate and demonstrated the systematic correlation of these biological effects between the physical properties of the ion. We also found that most of the induced DSBs were irreparable, which was due to the complexity of DNA damage. In addition, we showed evidence on the structural difference of DSB termini end depending on ion species.