Effects of chemical exposure on male reproductive organogenesis and functions

环境暴露于某些选定的化学物质对男性生殖器官和功能的影响在未暴露的一般受试者中进行了检查。目标化学物质和/或其代谢物的尿液浓度被用作暴露的生物标志物，出生时肛门生殖器距离（AGD）和精液参数分别被用于评估胎儿和成人暴露于目标化学物质的影响。在子宫内暴露于邻苯二甲酸二（2-乙基己基）发现缩短男性新生儿的AGD。研究发现，接触拟除虫菊酯杀虫剂会降低不育夫妇男性伴侣的精液活力。这些发现被认为是由于在环境水平上暴露于这些化学物质而干扰睾丸激素的作用或产生有关。

Effects of environmental exposure to some selected chemicals on male reproductive organs and functions were examined in non-exposed general subjects. Urinary concentration of the target chemicals and/or their metabolites was used as a biomarker of exposure and anogenital distance (AGD) at birth and semen parameters was used for the assessment of effect on fetal and adult exposure to the target chemicals, respectively. In utero exposure to phthalate di(2-ethylhexyl) was found to shorten AGD of male newborn. Exposure to pyrethroid insecticides was found to decrease semen motility in male partners of infertile couples. These findings were assumed to be related to interference on testosterone action or production due to exposure to these chemicals at environmental levels.