Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker

分析了自噬在小鼠各种组织损伤中的功能和表现模式。我们发现，在给予顺铂的小鼠肾脏中，自噬在早期被诱导，这是一种对顺铂诱导的肾损伤的保护性反应。我们还发现自噬在心肌肥大代偿期被诱导。在对皮肤创面愈合过程中自噬的分析中，我们发现创面部位的自噬立即减少，这可能是一种新的皮肤创面活力标志，对法医实践非常有用。

The function and pattern of appearance of autophagy in the various tissue injury were analyzed in the mouse models. We showed that autophagy was induced in early stage in the kidney of mice administrated with cisplatin, which was a protective response to cisplatin-induced renal injury. We also found that autophagy was induced in the compensatory stage of cardiac hypertrophy.In analysis of autophagy in the skin wound healing process, we found immediate reduction of autophagy in the wound sites,which might be very useful for forensic practice as a novel marker of vitality of skin wound.