A fundamental research on a new AIDS treatment based on an error rate control of HIV-1 reverse transcriptase

目前的项目旨在建立一种替代抗逆转录病毒治疗艾滋病的理论基础，这种治疗方法可以同时给艾滋病患者服用多种抗艾滋病毒药物。众所周知，HIV-1经常发生突变。另一种艾滋病治疗方法是通过诱导HIV-1 RNA（+）基因组过量突变，使HIV-1准物种群体自我毁灭。也就是说，它利用hiv -1容易出错的特性作为一种不正当的方式。本项目提出了一种新的HIV-1数学模型，考虑了病毒的动力学过程，如突变、复制、感染和致突变活动，以控制HIV-1突变率。该模型的数值模拟表明，HIV-1突变率的提高会对HIV-1准种群体产生“错误突变”。此外，对自毁状态的局部渐近稳定性分析表明，在特定的病毒条件下，替代艾滋病治疗是有效的。

The present project aims to establish theoretical bases on an alternative AIDS treatment for ART, which simultaneously administers multiple anti-HIV drugs to an AIDS patient. It is well known that HIV-1 is frequently-mutated. The alternative AIDS treatment is by inducing excess mutations to HIV-1 RNA(+) genome, to drive HIV-1 quasi-species population to self-destruction. Namely it uses the HIV-1error-prone character as an underhanded way. This project proposes a novel HIV-1 mathematical model considered viral kinetic processes such as mutation, replication, infection and mutagenic activities to control HIV-1 mutation rate. Numerical simulations of the model show that enhancement of a HIV-1 mutation rate causes an “error catastrophe”to HIV-1 quasi-species population. Furthermore, analyses of local asymptotic stability of the self-destruction state reveal that the alternative AIDS treatment haseffectiveness under certain specific viral conditions.