Association of serum cystatin C with the risk of the development of cardiovascular disease in a general Japanese population: the Hisayama Study

该项目的目的是在3，328名40岁或以上的日本社区居民中调查sCysC与动脉粥样硬化疾病风险的相关性。首先，我们研究了sCysC与外周动脉疾病（PAD）患病率（定义为踝臂指数<0.9）之间的关系。因此，PAD的未校正患病率随着sCysC水平的升高而线性增加。然而，在多变量校正分析中没有证据表明存在显著相关性。接下来，我们在上述人群中进行的平均7.1年随访研究中估计了sCysC与心血管风险的关联。高sCysC水平与未校正的心血管疾病发病率显著相关，但在校正混杂因素后，这种显著相关性消失。最后，我们在上述随访数据中评估了sCysC估计肾小球滤过率（eGFR-CysC）与心血管疾病发病风险和全因死亡率的关系。低eGFR-CysC是心血管疾病和全因死亡的危险因素。

The aims of this project were to investigate the association of sCysC on the risk of atherosclerotic disease among 3,328 community-dwelling Japanese individuals aged 40 years or older. First, we investigated the relationship between sCysC and prevalence of peripheral arterial disease (PAD) defined as ankle-brachial index <0.9. As a result, the unadjusted prevalence of PAD increased linearly with elevating sCysC levels. However, there was no evidence of the significant relationship in the multivariate-adjusted analysis. Next, we estimated the association of sCysC and the cardiovascular risk in an average 7.1-year follow-up study conducted in the above population. Higher sCysC levels were associated significantly with the unadjusted incidence of cardiovascular disease, but this significant association disappeared after adjusting confounding factors.Finally, we assessed the relationship between estimated glomerular filtration rate with sCysC (eGFR-CysC) and the risk of incident cardiovascular disease and all-cause mortalityin the above follow-up data. Lower eGFR-CysC was a risk factor for the incident cardiovascular disease and all-cause mortality.