Involvement of brain-derived neurotrophic factor gene polymorphism on the central nervous system disorders of alcoholics

戒酒可以部分改善酗酒者的认知功能障碍和脑萎缩。脑源性神经营养因子（BDNF）是一种调节脑内神经元生长、突触功能以及神经元存活和生长的因子，具有神经保护作用。BDNF基因的多态性与神经精神疾病如精神分裂症和情绪障碍的风险有关，尽管BDNF基因多态性与酒精中毒恢复之间的关系尚不清楚。在这项研究中，我们研究了这个问题。结果，我们发现对照组和患者组中BDNF基因多态性对任何神经影像学结果均无显著影响，这表明需要更多参与者进行进一步评估。

Cognitive dysfunction and brain atrophy observed in alcoholics could improve partially by abstinence. Brain-derived neurotrophic factor (BDNF), a factor adjusting the neuronal growth, synaptic functions, and survival and growth of neurons in the brain, shows neuroprotective effects. Polymorphism of the BDNF gene has been associated with risk of neuropsychiatric disorders such as schizophrenia and mood disorders, although relationship between BDNF gene polymorphism and recovery from alcohol intoxication is unclear. In this study, we examined this issue. As a result, we found no significant effect of BDNF gene polymorphism in the control as well as patients groups in any of neuroimaging findings, suggesting that further evaluations with more participants will be required.