Investigation of the central role of hepatic stellate cells in the tissue-repairing process of the liver

对非实质肝细胞，特别是肝星状细胞和肝窦内皮细胞在肝再生过程中的作用进行了研究，重点研究了这些细胞上机械应力受体的识别。同时，分析了肝手术患者围手术期门静脉血流动力学改变与肝再生的关系。因此，肝切除后的区域肝再生并不均匀，并且与每个患者先前门脉血流分布的变化密切相关。此外，在切除的人肝组织中发现了几个机械应激受体，通过对一些蛋白质的鉴定，怀疑在这些受体下存在信号转导通路。

The role of non-parenchymal hepatic cells, especially hepatic stellate cells and sinusoidal endothelial cells, in liver regeneration process was investigated focusing on the identification of mechanical stress-receptors on these cells. Meanwhile, relationship between the perioperative change in portal hemodynamics and the regional liver regeneration was analyzed in humans who underwent hepatic surgery. As a result, regional liver regeneration was not homogeneous after hepatic resection, and well correlated with preceding changes in portal flow distribution in each patient. Moreover, several mechanical stress-receptors were identified in resected human liver tissues, and existence of signal transduction pathways under the receptors was suspected by identification of some proteins.