Development of new efficient cancer-specific artificial viral transduction system

通过对胰腺癌细胞内吞途径的研究，发现腺病毒转基因表达量一直在下降，整合素β3的表达水平一直高于β5。此外，我们可以将吉西他滨和整合素β3的siRNA包封到源自最初开发的詹氏甲烷球菌古细菌产生的小热休克蛋白的蛋白纳米胶囊Mj285（人工病毒）上。此外，我们可以通过酰胺键生物缀合将病毒与抗体MUC 1结合。

Through the study of endocytosis pathway in pancreatic cancer, we found that adenovirus transgene expression has been declining which had been higher expression level of integrinβ3 thanβ5. In addition, we can encapsulate gemcitabine and siRNA of integrinβ3 to the protein nanocapsule Mj285(artificial virus) derived from the small heat shock protein produced by originally developed archaea Methanococcusjannaschii. Furthermore we can bind the virus to the antibody MUC1 by amide bond bioconjugation.