Glutamine-glutamate recycle system in the inner ear

谷氨酸参与了Corti器官内毛细胞和传入纤维之间的信号传递。内毛细胞富含谷氨酸，突触后膜表达AMPA谷氨酸受体。然而，尚不清楚内毛细胞是否含有补充谷氨酸的机制。这样的机制必须到位，以维持谷氨酸的神经传递。在这里，我们提供了RT-PCR和免疫荧光数据，表明A系统转运蛋白1(SLC38A1)在内毛细胞中表达，它与中枢神经系统谷氨酰胺转运和神经递质GABA和谷氨酸的合成有关。

Glutamate has been implicated in signal transmission between inner hair cells and afferent fibers of the organ of Corti. The inner hair cells are enriched in glutamate and the postsynaptic membranes express AMPA glutamate receptors. However, it is not known whether inner hair cells contain a mechanism for glutamate replenishment. Such a mechanism must be in place to sustain glutamate neurotransmission. Here we provide RT -PCR and immunofluorescence data indicating that system A transporter 1 (SLC38A1), which is associated with neuronal glutamine transport and synthesis of the neurotransmitters GABA and glutamate in CNS, is expressed in inner hair cells.