Basic research of the development of new pulp capping agent

磷蛋白是牙本质矿化的重要蛋白。从猪牙齿中提取，并与1型胶原蛋白结合作为试验材料。将该材料置于8周龄Wistar大鼠上颌第一磨牙外露牙髓上。术后2 ~ 4周处死大鼠，采用自动磨床切割中、远端牙面。切片扫描电镜分析。试验材料组修复牙本质具有牙本质小管，与普通材料氢氧化钙相比，足以封闭暴露的牙髓区域。因此，该材料具有作为氢氧化钙替代材料的潜力。

Phosphophoryn is an important protein in dentin mineralization. It was extracted from porcine teeth, and was combined with type 1 collagen as a trial material. This trial material was placed onto the exposed pulp in maxillary first molar of 8 week-old Wistar rats. Rats were sacrificed 2-4 weeks after operation, and teeth were cut for mesial-distal plane by using an automatic grinder. Sections were analyzed by scanning electron microscopy. In trial material group, reparative dentin had dentinal tubules, and enough to seal exposed pulp area compared with calcium hydroxide, a common material. Therefore, this material was suggested to have a potential as an alternative material of calcium hydroxide.