The mechanism for length regulation of thick filament by muscle elastic protein connectin

我们发现了一种与肌肉弹性蛋白连接蛋白结合的新蛋白质。我们的分析表明，该蛋白位于横纹肌肌球蛋白丝和神经元-肌肉交界处的边缘，该蛋白的基因包括25个外显子，产生5个剪接异构体。此外，我们还鉴定了新蛋白的结合蛋白和分解蛋白，并在包括人类和果蝇在内的多种动物中发现了该蛋白的存在。

We found a novel protein that binds to muscle elastic protein connectin. Our analysis indicates this protein locates at the edge of myosin filament and neuron-muscular junction on striated muscles, and the gene of this protein includes twenty-five exons and produces five splicing isoforms. Additionally, we identified the binding proteins and a break-down protein of novel protein, and also found the existence of this protein in various animals including human and Drosophila.