Mechanisms of the spindle assembly checkpoint silencing by kinetochore stretching

动粒伸展是动粒伸展和回缩的重复循环，在双向后使纺锤体组装检查点失活。同时，通过完整的拉力将张力施加在姐妹运动心线上。人们认为，这种紧张局势也会使检查站失灵。在这项研究中，我证明了动粒拉伸依赖的检查点沉默与张力依赖的检查点沉默是独立的

Kinetochore stretching, repetitive cycles of kinetochore extension and recoiling, inactivates the spindle assembly checkpoint after biorientation. At the same time, tension is applied across sister kinetochores by intact pulling force. It is thought that this tension also inactivates the checkpoint. In this study, I demonstrated that kinetochore stretching-dependent checkpoint silencing is independent from tension-dependent checkpoint silencing