Elucidation of the role of Pin1 on the adipose differentiation

我们报道了Pin1与Crtc2结合并抑制肝脏中CRE转录和糖异生活性。此外，Pin1与主要胰岛素受体底物IRS-1结合，并增强胰岛素诱导的代谢作用。Pin1与IRS-1和Crtc2的关联最终导致了过量营养物质进入组织，这是基于Pin1在体外和体内过表达、基因沉默、一种特异性抑制剂和Pin1敲除小鼠获得的一系列数据得出的。此外，研究表明，Pin1也是前脂肪细胞向成熟脂肪细胞分化所必需的。

We reported that Pin1 binds to Crtc2 and suppresses CRE transcriptional and gluconeogenic activity in the liver. In addition, Pin1 associates with IRS-1, a major insulin receptor substrate, and enhances insulin-induced metabolic actions. The associations of Pin1 with IRS-1 and Crtc2 ultimately contribute to the incorporation of excess nutrients into tissues, based on a data series obtained using in vitro and in vivo over-expressions of Pin1, gene silencing, a specific inhibitor and Pin1 knock-out mice. In addition, it was shown that Pin1 is also indispensable for differentiation from pre-adipocytes into mature adipocytes.