Relation between epigenetic regulation by postprandial hyperglycemia and development of metabolic diseases

在这项研究中，我们发现Brd4蛋白作为一种新的表观遗传因子，通过引导碳水化合物摄入诱导的组蛋白修饰来提高mRNA水平。Brd4通过在碳水化合物反应基因的转录区域招募正延长因子b(P-TEFb)来增强转录，这些基因包括小肠中的碳水化合物消化和吸收相关基因以及脂肪细胞中的胰岛素敏感基因。此外，我们还发现Brd4表达增加会导致小鼠肥胖、胰岛素抵抗。此外，我们还发现血液中的Brd4靶蛋白如ALBP、ALT是人类肥胖和胰岛素抵抗的有用生物标志物。

In this study, we found the Brd4 protein as a new epigenetic factor to enhance mRNA levels by leading histone modifications induced by carbohydrate intake. The Brd4 enhances transcription by recruiting positive elongation factor b (P-TEFb) on transcribed region of carbohydrate-responsive genes such as carbohydrate digestion and absorption-related genes in the small intestine and insulin sensitivity genes in adipocytes. In addition, we found that increased Brd4 expression induces obesity, insulin resistance in mice. Furthermore, we found Brd4 target proteins in blood such as ALBP, ALT are useful biomarkers for obesity and insulin resistance in human.