Tumorigenesis triggered by the misregulation of the Wnt signaling pathways in mitosis

作为Wnt信号通路之一，β依赖的连环蛋白通路通过转录激活促进了G1/S的进程，编码该通路的基因突变触发了肿瘤的发生。然而，Wnt信号通路在有丝分裂进程中的作用尚不清楚。我们发现，在中期，依赖于β的连环蛋白途径的组成部分调节纺锤体的方向，而其他Wnt信号途径，-β连环蛋白不依赖的途径控制细胞动力学脱落的完成。我们的发现表明，Wnt信号通路控制着有丝分裂中的多个事件。

One of the Wnt signaling pathways, theβ-catenin-dependent pathway contributes to G1/S progression through transcriptional activation, and mutations in the genes encoding the pathway trigger tumorigensis. However, involvement of the Wnt signaling pathways in mitotic progression remains unclear. We found that the components of theβ-catenin-dependent pathway regulate spindle orientation in metaphase, and other Wnt signaling pathways, the-βcatenin-independent pathway controls the completion of cytokinetic abscission. Our findings suggest that the Wnt signaling pathways govern multiple events in mitosis.