Emerging pathophysiological roles of ganglioside GM3

我们发现CD8T细胞表达非常高水平的o系列神经节苷脂，而另一方面，CD4T细胞更好地表达a系列神经节苷脂。在TCR依赖性激活中，CD4T细胞选择性地需要a系列神经节苷脂，而CD8T细胞只需要o系列神经节苷脂而不需要a系列神经节苷脂。神经节苷脂GM3合成酶缺乏a系列神经节苷脂的小鼠既没有表现出tcr依赖性的CD4T激活，也没有发生卵清蛋白诱导的过敏性气道炎症。这些发现表明，CD4T和CD8T细胞中神经节苷类的不同表达模式决定了每个T细胞亚群的免疫功能。我们还提出了一个工作假设=代谢性疾病，如2型糖尿病，是由神经节苷脂异常表达引起的膜微结构域紊乱=。

We have found that CD8T cells express very high levels of o-series gangliosides, but on the other hand, CD4T cells preferably express a-series gangliosides. In the TCR dependent activation, CD4T cells selectively require a-series gangliosides, but CD8T cells do require only o-series gangliosides but not a-series gangliosides. Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4T nor developed ovalbumin-induced allergic airway inflammation. These findings imply that the distinct expression pattern of ganglioside species in CD4T and CD8T cells define the immune function of each T cell subset.We also propose a working hypothesis =metabolic disorders, such as type2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides=.