Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.

日本的肝移植主要是活体供肝移植。随着近年来人口老龄化的加剧，供者肝脏的老化已成为最大的问题。我们给出了类似于肝移植的手术侮辱，包括缺血再灌注损伤和老年肝脏的大范围肝切除。关于衰老导致肝功能和再生功能不全的机制，我们获得了一些新的发现。我们还发现了一些可能的治疗药物和策略，包括ADRC、HDAC抑制剂等，这些药物和策略可能改善这些动物模型的肝功能，并可能支持肝再生。

The majority of liver transplantation in Japan is living donor liver transplantation. As aging population has recently been increasing, aged liver of a donor candidate has become a most problem. We gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the aged liver. We obtained several novel findings regarding the mechanisms, by which aging induced liver functional and regenerative insufficiency. We also found some possible therapeutic agents and strategies including ADRC, HDAC inhibitor and the others, which may improve the liver dysfunction and may support liver regeneration in these animal models.