Study on the elucidation and prevention for cardiovascular disorder by HACEK group oral bacteria

一些微生物学和流行病学研究表明，口腔细菌与糖尿病、呼吸系统疾病和心血管疾病等全身健康之间存在关联。口腔细菌中的Hacek细菌(嗜血杆菌属、Aggregatibacter属、人心杆菌属、腐蚀性艾肯氏杆菌属、金格拉杆菌属)是感染性心内膜炎的病原体。本研究旨在探讨伴生放线杆菌和产甲烷古菌在感染性心内膜炎发病中的可能致病因素，并分析感染性心内膜炎患者的临床和微生物学特征。进一步鉴定了放线菌伴生菌和产甲烷古生菌II组伴侣蛋白中的细胞表面烯醇化酶和RNA伴侣蛋白Hfq。此外，还考察了蛋氨酸氨基肽酶抑制剂和维生素K类似物作为新治疗药物候选药物的抗菌活性。

Several microbiologic and epidemiologic studies have suggested an association between oral bacteria and systemic health such as diabetes, respiratory diseases and cardiovascular diseases. The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) among oral bacteria are noted as the pathogens of infective endocarditis. The aim of this study is to determine the possible pathogenic factors of Aggregatibacter actinomycetemcomitans and oral methanogenic Archaea on infective endocarditis, and to analyze clinical and microbiological characteristics of the patients with infective endocarditis. Cell surface enolase and RNA chaperone protein, Hfq in A. actinomycetemcomitans and group II chaperonin of oral methanogenic Archaea were further characterized. The antimicrobial activity of inhibitor for methionine aminopeptidase and vitamin K analogues were also examined as a candidate of new therapeutic agents.