Induction of neurogenesis from endogenous neural precursors in the adult brain after stroke by long-term voluntary execise

长期自愿运动(EX)可减少易卒中遗传性高血压大鼠(SHRSP)的卒中事件。能缩小脑损伤体积，改善神经功能缺陷，延长中风后EX大鼠的寿命。修复受损中枢神经系统的可能策略包括：(1)激活内源性神经干细胞(NSC)；(2)改变卒中病变周围的微环境以促进其发育和分化；(3)促进内皮祖细胞(EPC)和NSC的迁移。我们发现Ex增加了NSC和EPC的数量，并促进了它们在侧肺和脑损伤中的分化。对骨髓细胞衰老有抑制作用。EX组大鼠血浆、脑脊液和皮损中炎性因子的产生也明显减少。这种改善可能取决于不生产。神经生长因子和趋化因子包括脑源性神经营养因子、成纤维细胞生长因子、表皮生长因子、IGF-1和CXCL12在卒中后早期产生。

Long-term voluntary exercise (EX) decreased stroke events in stroke-prone genetically hypertensive rats (SHRSP). Volume of cerebral lesion was also reduced and neural defects were improved, resulting in prolonged life span in post-stroke EX rats. Possible strategies for regenerating damaged central nervous system;(1)activation of endogenous neural stem (progenitor) cells (NSC) (2)modification of microenvironment surrounding stroke lesion for their development and differentiation (3)enhanced migration of endothelial progenitor cells (EPC) and NSC. We found that Ex increased the number of NSC and EPC, and enhaced their differentiation in lateral venticle and cerebral lesion. Cell senescence in bone marrow was suppressed by EX. Production of inflammatory factors in plasma, CSF and lesion was also decreased in EX rats. The improvement may depend on NO production. Nerve growth factors and chemokine including BDNF, FGF, EGF, IGF-1 and CXCL12 were produced in early phase after stroke in EX.