Study on physiological function of the bivalve mainly on lipid metabolism

我们研究了淡水蛤（Corbicula fluminea）对胆固醇代谢的影响。 从河蚬（Corbicula fluminea）的热水提取物的脂质部分中提取的活性成分的结构是神经酰胺磷酸酯分子种类。我们使用所有RNA进行微阵列分析并进行生物信息学分析。在给予脂质组分的大鼠中观察到胆固醇催化活性的促进和脂肪酸合成酶活性的显著抑制。 此外，还表明脂质部分对SREBP蛋白质的加工有作用。 在给予蛋白质组分的大鼠中也观察到胆固醇催化剂的促进作用。

We examined effects of the Freshwater Clam (Corbicula fluminea) on cholesterol metabolism. The structure of the active ingredient in the lipid fraction of the heated water extract of the Freshwater Clam (Corbicula fluminea) was a ceramide phosphoramidate molecular species.We extracted RNA from the liver of rat given the lipid fraction or the protein fraction. We performed microarray analysis using all RNA and analyzed bioinformatics. Promotion of the cholesterol catabolism and remarkable depression of activities of enzymes of fatty acid synthesis were seen in the rat given the lipid fraction. In addition, it was suggested that the lipid fraction acted on processing of the protein of SREBP. Promotion of the cholesterol catabolism was also seen in the rat given the protein fraction.