Multilateral verification of preventive effects of polyunsaturated fatty acids on dementia

从人体干预预防痴呆研究的亚分析来看，两组根据12个月内总MMSE （dMMSE）评分的平均变化进行细分如下：应答者，总dMMSE变化bb0 0；无应答者，dMMSE总分变化< 0。有反应者血浆ldl -胆固醇和红细胞二十碳五烯酸水平明显高于无反应者，说明老年人的营养状况反映在dha强化食物对痴呆的预防效果上。5去饱和酶的遗传多态性在两组间无明显差异。利用TSQ量子质谱仪，发现dha给药老年大鼠空间认知学习能力的提高与dha衍生代谢物的脑内水平呈正相关。建立了大鼠海马DHA减少的成像质谱可视化方法。

From the sub-analysis of human interventional studies on dementia prevention, both the groups were subdivided according to the mean changes in the total MMSE (dMMSE) scores over 12 months as following: responders, total dMMSE change > 0; nonresponders, total dMMSE score change < 0. The levels of plasma LDL-cholesterol and erythrocyte eicosapentaenoic acid were significant higher in the responders than those in the nonresponders, suggesting that the nutrition status of the elderly is reflected in dementia preventive effect by DHA-enriched food. The differences of genetic polymorphisms of delta 5 desaturase were, however, not observed between two groups.Using a TSQ quantum mass spectrometer, the positive correlation between the improvement of spatial cognitive learning ability in DHA-administrated aged rats and the brain levels of DHA-derived metabolites was found. Visualization of decreased DHA in the hippocampus of rats by imaging mass spectrometry was established.