Regulation of neural functions via polySia and FGF2 interaction

聚唾液酸（polySia）是一种唾液酸的均聚物，聚合度为8-400个Sia残基。PolySia在胚胎脑的神经细胞粘附分子（neural cell adhesion molecule, ncm）上高度表达。成虫息肉病基本消失；然而，它持续存在于不同的区域，如海马、脑室下区、丘脑、前额叶皮层和杏仁核，在这些区域，神经可塑性、神经连接重塑或神经生成正在进行。由于其庞大的多阴离子性质，已知NCAM上的聚sia对细胞间相互作用具有抗粘附作用，并参与神经发生和神经元功能的调节。在这项研究中，我们证明了polySia作为各种神经活性分子分子的储层支架，如成纤维细胞生长因子2 （FGF2）。

Polysialic acid (polySia) is a homopolymer of sialic acid with the degree of polymerization 8-400 Sia residues. PolySia is highly expressed on the neural cell adhesion molecule (NACM) in embryonic brains. In adult, polySia mostly disappeared; however, it persists in distinct regions such as hippocampus, subventricular zone, thalamus, prefrontal cortex and amygdala, where neural plasticity, remodeling of neural connections or neural generation are ongoing. PolySia on NCAM is known to have anti-adhesive effects on cell-cell interactions due to its bulky polyanionic nature and is involved in regulation of neurogenesis and neuronal functions. In this study, we demonstrate that polySia functions as a reservoir scaffold for various molecules of neurological active molecules, such as fibroblast growth factor 2 (FGF2).